壞消息：肥胖不光醜，而且還致癌大綱

A new discovery could explain why obese people are more likely to develop cancer, scientists say. A type of cell the body uses to destroy cancerous tissue gets clogged by fat and stops working, the team, from Trinity College Dublin, found.
科學家們表示，現在有一項新研究可能可以解釋爲什麼肥胖的人更可能得癌症。一個來自都柏林三一學院的團隊發現，我們身體用來破壞癌變組織的一種細胞會被脂肪堵塞並停止工作。

Obesity is the biggest preventable cause of cancer in the UK after smoking, Cancer Research UK says. And more than one in 20 cancer cases - about 22,800 cases each year in the UK - are caused by excess body weight.
據英國的癌症研究學會說，肥胖在英國是僅次於吸菸的可預防型癌症原因。而且有超過1/20的癌症案例都是由超重引起的，這在英國每年就有差不錯22800例。

Experts Already suspected fat sent signals to the body that could both damage cells, leading to cancer, and increase the number of them. Now, the Trinity scientists have been able to show, in Nature Immunology journal, how the body's cancer-fighting cells get clogged by fat.
專家們以前就在懷疑脂肪給身體傳遞的一些信號會損害我們的細胞、引發癌症並增加癌變細胞的數量。而跟根這次據三一學院的科學家在《自然免疫學》期刊上發表的研究，他們已經能夠展示出脂肪是如何堵塞那些抗癌細胞的了。

And they hope to be able to find drug treatments that could restore these "natural killer" cells' fighting abilities.
他們希望能找出一種藥物療法來幫這些“天生的癌症殺手細胞”恢復戰鬥能力。

Prof Lydia Lynch said: "A compound that can block the fat uptake by natural killer cells might help. We tried it in the lab and found it allowed them to kill again. But arguably a better way would be to lose some weight - because that is healthier for you anyway."
Lydia Lynch教授說：“有一種化合物可以防止這些癌症殺手細胞吸收脂肪，我們可能可以用它。我們已經在實驗室裏試過這種物質了，發現它讓癌症殺手細胞得以重新開始擊殺。不過更好的辦法應該還是減肥，畢竟那能讓你更健康。”

Dr Leo Carlin, from the Cancer Research UK Beatson Institute, said: "Although we know that obesity increases the risk of 13 different types of cancer, we still don't fully understand the mechanisms underlying the link.
來自英國癌症研究學會比斯頓研究所的Leo Carlin博士說：“雖然我們知道肥胖能夠提升13種不同癌症的發病率，但我們還沒有完全明白具體的機制。”

"This study reveals how fat molecules prevent immune cells from properly positioning their tumour-killing machinery, and provides new avenues to investigate treatments. A lot of research focuses on how tumours grow in order to find metabolic targets to stop them, so this is a reminder that we should consider the metabolism of immune cells too."
“而這次的研究讓我們明白了脂肪分子是如何阻礙免疫細胞的抗癌機制的，也爲我們尋找相關治療方法指明瞭新方向。已經有很多研究着眼於腫瘤的生長，以希望能找到從新陳代謝角度阻止他們的方法；而我們這次研究則提醒我們或許也應該研究一下免疫細胞的新陳代謝機制。”